Vitamin D, calcium, and sarcoidosis
Identifieur interne : 002A67 ( Main/Exploration ); précédent : 002A66; suivant : 002A68Vitamin D, calcium, and sarcoidosis
Auteurs : O. P. Sharma [États-Unis]Source :
- Chest [ 0012-3692 ] ; 1996.
Descripteurs français
- Pascal (Inist)
- Wicri :
English descriptors
- KwdEn :
Abstract
Hypercalcemia occurs in about 10% of the patients with sarcoidosis ; hypercalciuria is about three times more frequent. These abnormalities of calcium metabolism are due to dysregulated production of 1,25-(OH) 2-D3 (calcitriol) by activated macrophages trapped in pulmonary alveoli and granulomatous inflammation. Undetected hypercalcemia and hypercalciuria can cause nephrocalcinosis, renal stones, and renal failure. Corticosteroids cause prompt reversal of the metabolic defect. Chloroquine, hydroxychloroqune, and ketoconazole are the drugs that should be used if the patient fails to respond or develops dangerous side effects to corticosteroid therapy.
Affiliations:
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Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en" level="a">Vitamin D, calcium, and sarcoidosis</title><author><name sortKey="Sharma, O P" sort="Sharma, O P" uniqKey="Sharma O" first="O. P." last="Sharma">O. P. Sharma</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>USC school medicine, dep. pulmonary critical care medicine</s1><s2>Los Angeles CA</s2><s3>USA</s3></inist:fA14><country>États-Unis</country><wicri:noRegion>Los Angeles CA</wicri:noRegion></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">INIST</idno><idno type="inist">96-0152443</idno><date when="1996">1996</date><idno type="stanalyst">PASCAL 96-0152443 INIST</idno><idno type="RBID">Pascal:96-0152443</idno><idno type="wicri:Area/PascalFrancis/Corpus">000088</idno><idno type="wicri:Area/PascalFrancis/Curation">000082</idno><idno type="wicri:Area/PascalFrancis/Checkpoint">000086</idno><idno type="wicri:explorRef" wicri:stream="PascalFrancis" wicri:step="Checkpoint">000086</idno><idno type="wicri:doubleKey">0012-3692:1996:Sharma O:vitamin:d:calcium</idno><idno type="wicri:Area/Main/Merge">002B20</idno><idno type="wicri:Area/Main/Curation">002A67</idno><idno type="wicri:Area/Main/Exploration">002A67</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a">Vitamin D, calcium, and sarcoidosis</title><author><name sortKey="Sharma, O P" sort="Sharma, O P" uniqKey="Sharma O" first="O. P." last="Sharma">O. P. Sharma</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>USC school medicine, dep. pulmonary critical care medicine</s1><s2>Los Angeles CA</s2><s3>USA</s3></inist:fA14><country>États-Unis</country><wicri:noRegion>Los Angeles CA</wicri:noRegion></affiliation></author></analytic><series><title level="j" type="main">Chest</title><title level="j" type="abbreviated">Chest</title><idno type="ISSN">0012-3692</idno><imprint><date when="1996">1996</date></imprint></series></biblStruct></sourceDesc><seriesStmt><title level="j" type="main">Chest</title><title level="j" type="abbreviated">Chest</title><idno type="ISSN">0012-3692</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Calcium</term><term>Human</term><term>Hypercalcemia</term><term>Inorganic element</term><term>Macrophage</term><term>Metabolism</term><term>Pulmonary alveolus</term><term>Sarcoidosis</term><term>Vitamin D</term></keywords><keywords scheme="Pascal" xml:lang="fr"><term>Sarcoïdose</term><term>Homme</term><term>Calcium</term><term>Vitamine D</term><term>Métabolisme</term><term>Macrophage</term><term>Hypercalcémie</term><term>Alvéole pulmonaire</term><term>Kétoconazole</term><term>Elément minéral</term></keywords><keywords scheme="Wicri" type="topic" xml:lang="fr"><term>Homme</term><term>Calcium</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Hypercalcemia occurs in about 10% of the patients with sarcoidosis ; hypercalciuria is about three times more frequent. These abnormalities of calcium metabolism are due to dysregulated production of 1,25-(OH) <sub>2</sub>-D<sub>3</sub> (calcitriol) by activated macrophages trapped in pulmonary alveoli and granulomatous inflammation. Undetected hypercalcemia and hypercalciuria can cause nephrocalcinosis, renal stones, and renal failure. Corticosteroids cause prompt reversal of the metabolic defect. Chloroquine, hydroxychloroqune, and ketoconazole are the drugs that should be used if the patient fails to respond or develops dangerous side effects to corticosteroid therapy.</div></front></TEI><affiliations><list><country><li>États-Unis</li></country></list><tree><country name="États-Unis"><noRegion><name sortKey="Sharma, O P" sort="Sharma, O P" uniqKey="Sharma O" first="O. P." last="Sharma">O. P. Sharma</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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